High potency medical probiotic may ease depressive symptoms: RCT

Via Peters

Data published in Translational Psychiatry, ​a Nature ​journal, ​indicated that a combination of Streptococcus, Bifidobacterium​, and Lactobacillus​ strains called the De Simone Formulation, used in addition to customary depression treatments, decreased depressive symptom outcomes relative to the placebo, but only when the study participants complied with the protocol.

“In our study probiotic effects were only significant in a subsample with high compliance and accentuated in the follow-up after eight weeks, indicating a remission rate of 55% in the probiotics group compared to a 40% remission rate in the placebo group,” ​reported scientists from the University of Basel in Switzerland.

“The importance of compliance during probiotic supplementation should be highlighted and is as important as in general antidepressant therapy.”

The formulation

The De Simone Formulation probiotic is distributed in North America by Rockville, Maryland-based ExeGi Pharma under the brand name, Visbiome. It is available as a medical food for the dietary management of dysbiosis associated with IBS, ulcerative colitis, pouchitis and hepatic encephalopathy. In Europe, it is sold under the name Vivomixx.

The formulation includes Streptococcus thermophilus, Bifidobacterium breve, B. longum, B. infantis, Lactobacillus acidophilus, L. plantarum, L. para-casei, ​and L. delbrueckii​ subsp. bulgaricus.

Microbiota-gut-brain axis

The study adds to the ever-growing area of research around the microbiota-gut-brain axis, that bi-directional interaction between the gastrointestinal tract and the nervous system. The area is gaining increasing attention from scientists and consumers.


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