More than 400,000 children and young people a month are being treated for mental health problems – the highest number on record – prompting warnings of an unprecedented crisis in the wellbeing of under-18s. Experts say Covid-19 has seriously exacerbated problems such as anxiety, depression and self-harm among school-age children […]
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Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials
Summary Background For women with early-stage oestrogen receptor (ER)-positive breast cancer, adjuvant tamoxifen reduces 15-year breast cancer mortality by a third. Aromatase inhibitors are more effective than tamoxifen in postmenopausal women but are ineffective in premenopausal women when used without ovarian suppression. We aimed to investigate whether premenopausal women treated […]