Metformin in Treatment-Resistant Bipolar Depression

Via Peters

Adjunctive metformin in bipolar disorder. Researchers performed a randomized clinical trial of treating insulin resistance to improve clinical outcomes in treatment-resistant bipolar depression. RESEARCH UPDATE Treatment-resistant bipolar depression (TRBD) is defined by non-remission after 2 8-week trials of recommended medications, including combination therapy, at therapeutic doses, and associated with increased […]

Defining and Recognizing Treatment-Resistant Depression (TRD)

Via Peters

Steve Levine, MD: Hello, and welcome to this AJMC® program “Improving Access to Alternative Therapies for Treatment-Resistant Depression.” I’m Dr Steve Levine, cofounder and non-executive chairman of the board of Heading Health in Austin, Texas, and senior vice president of patient access and medical affairs for COMPASS Pathways. Joining me […]

Pharmacogenetic testing shows promise improving symptoms in patients with treatment-resistant depression — ScienceDaily

Via Peters

Pharmacogenetic testing was associated with nearly a two-fold (89 per cent) increase in remission rates compared to treatment as usual in a Centre for Addiction and Mental Health- (CAMH-)led clinical study just published in the journal Translational Psychiatry. The 52-week double-blind study, comparing pharmacogenetic testing guided treatment to treatment as […]

The Neglected Role of Psychotherapy for Treatment-Resistant Depression

Via Peters

The concept of treatment-resistant or treatment-refractory depression (TRD) has evolved over 40 years since the recognition that some patients minimally benefit from repeated antidepressant medication trials. No uniform definition exists for TRD (1–10). What constitutes TRD has unfortunately varied across settings and literature reviews, differing in defining trial adequacy, nonresponse, […]

Getting a Clearer Picture of Treatment-Resistant Depression

Via Peters

What is treatment-resistant depression? New report calls for clearer definition to inform research and improve treatment.A group of mental health experts from research, industry, regulatory bodies and with lived experience have proposed new agreed criteria to define the type of depression that current medications and therapies cannot treat effectively. The […]

What is treatment-resistant depression? New report calls for clearer definition to inform research and improve treatment.

Via Peters

Newswise — A group of mental health experts from research, industry, regulatory bodies and with lived experience have proposed new agreed criteria to define the type of depression that current medications and therapies cannot treat effectively. The report aims to provide consistent definitions for future research, and especially for designing […]